Gideon M Hirschfield Selected Research

Sclerosing Cholangitis

6/2021	Potent suppression of hydrophobic bile acids by aldafermin, an FGF19 analogue, across metabolic and cholestatic liver diseases.
1/2021	Inter- and Intra-individual Variation, and Limited Prognostic Utility, of Serum Alkaline Phosphatase in a Trial of Patients With Primary Sclerosing Cholangitis.
7/2020	A Pilot Integrative Analysis of Colonic Gene Expression, Gut Microbiota, and Immune Infiltration in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease: Association of Disease With Bile Acid Pathways.
1/2020	A randomized, placebo-controlled, phase II study of obeticholic acid for primary sclerosing cholangitis.
1/2019	Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System.
1/2019	Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial.
1/2019	British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis.
11/2018	Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells.
8/2018	Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease.
1/2018	Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

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Gideon M Hirschfield Research Topics

Disease

48	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2022 - 05/2008
27	Sclerosing Cholangitis 06/2021 - 01/2009
22	Liver Diseases (Liver Disease) 12/2021 - 01/2009
14	Pruritus (Itching) 01/2022 - 08/2010
13	Autoimmune Hepatitis 04/2022 - 01/2009
13	Fibrosis (Cirrhosis) 06/2021 - 10/2010
12	Inflammation (Inflammations) 01/2022 - 04/2004
10	Autoimmune Diseases (Autoimmune Disease) 11/2019 - 05/2008
8	Cholestasis 01/2022 - 06/2013
8	Disease Progression 01/2022 - 05/2011
8	Neoplasms (Cancer) 10/2020 - 02/2016
6	Liver Cirrhosis (Hepatic Cirrhosis) 01/2021 - 01/2016
5	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 07/2020 - 01/2014
4	Cholangitis 12/2020 - 06/2009
4	Hepatitis 05/2019 - 02/2012
3	End Stage Liver Disease 06/2021 - 04/2016
3	Genetic Predisposition to Disease (Genetic Predisposition) 03/2019 - 05/2013
2	Alcoholic Fatty Liver 06/2021 - 11/2019
2	Hemorrhage 01/2021 - 01/2019
2	Fatigue 01/2019 - 08/2010
2	Immunoglobulin G4-Related Disease 01/2018 - 06/2014
2	Bile Duct Diseases (Bile Duct Disease) 01/2018 - 01/2017
2	Hepatolenticular Degeneration (Wilson's Disease) 11/2017 - 06/2012
2	Pathologic Constriction (Stenosis) 11/2017 - 06/2014
2	Necrosis 06/2016 - 04/2006
2	Chronic Hepatitis C 06/2015 - 02/2014
2	Infections 06/2015 - 02/2014
2	Atherosclerosis 01/2008 - 06/2005
2	Acute-Phase Reaction 06/2005 - 12/2003
1	Body Weight (Weight, Body) 01/2021
1	Colorectal Neoplasms (Colorectal Cancer) 01/2020
1	Polyps 01/2020

Drug/Important Bio-Agent (IBA)

29	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 01/2022 - 01/2009
16	Alkaline PhosphataseIBA 01/2022 - 10/2010
11	Bile Acids and Salts (Bile Acids)IBA 06/2021 - 05/2011
10	AntibodiesIBA 01/2021 - 05/2008
9	Biomarkers (Surrogate Marker)IBA 01/2022 - 04/2010
9	BilirubinIBA 12/2021 - 06/2014
8	obeticholic acidIBA 02/2021 - 04/2015
7	Immunoglobulin G (IgG)IBA 04/2022 - 01/2009
6	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 09/2011
6	AutoantibodiesIBA 02/2015 - 04/2010
4	Aspartate Aminotransferases (Aspartate Transaminase)IBA 06/2021 - 02/2016
4	Interleukin-12 (IL 12)IBA 11/2018 - 06/2009
4	Pharmaceutical PreparationsIBA 01/2017 - 02/2012
4	Proteins (Proteins, Gene)FDA Link 06/2013 - 02/2004
3	Alanine Transaminase (SGPT)IBA 06/2021 - 04/2015
3	DNA (Deoxyribonucleic Acid)IBA 10/2020 - 06/2009
3	3- ((((3R,5R)- 3- butyl- 3- ethyl- 7- (methyloxy)- 1,1- dioxido- 5- phenyl- 2,3,4,5- tetrahydro- 1,4- benzothiazepin- 8- yl)methyl)amino)pentanedioic acidIBA 01/2019 - 07/2016
3	bile acid binding proteinsIBA 01/2019 - 07/2016
3	AntigensIBA 08/2018 - 01/2018
3	Biological ProductsIBA 02/2016 - 01/2009
3	CholesterolIBA 06/2013 - 04/2004
3	EnzymesIBA 02/2012 - 12/2010
3	C-Reactive ProteinIBA 04/2006 - 04/2004
2	seladelparIBA 01/2022 - 10/2017
2	Hormones (Hormone)IBA 06/2021 - 01/2019
2	aldaferminIBA 06/2021 - 01/2019
2	Protons (Proton)IBA 06/2021 - 01/2018
2	ParaffinIBA 10/2020 - 08/2018
2	Formaldehyde (Formol)FDA Link 10/2020 - 08/2018
2	Immunoglobulin M (IgM)IBA 09/2020 - 02/2012
2	AlbuminsIBA 09/2020 - 01/2019
2	sodium-bile acid cotransporterIBA 01/2020 - 03/2019
2	SteroidsIBA 12/2019 - 01/2014
2	Complement C3 (C3 Complement)IBA 01/2019 - 06/2005
2	Cholestyramine Resin (Questran)FDA LinkGeneric 01/2019 - 08/2010
2	Rifampin (Rifampicin)FDA LinkGeneric 01/2019 - 08/2010
2	CopperIBA 11/2017 - 06/2012
2	HLA Antigens (Human Leukocyte Antigens)IBA 01/2017 - 05/2016
2	AcidsIBA 01/2017 - 04/2015
2	LigandsIBA 06/2016 - 04/2006
2	Ribavirin (Virazole)FDA LinkGeneric 06/2015 - 02/2014
2	Immunoglobulins (Immunoglobulin)IBA 06/2015 - 05/2015
2	Vitamin D FDA LinkGeneric 07/2014 - 08/2010
2	Azathioprine (Imuran)FDA LinkGeneric 02/2012 - 01/2009
2	Apolipoproteins E (ApoE)IBA 01/2008 - 06/2005
2	ApolipoproteinsIBA 01/2008 - 06/2005
2	Acute-Phase Proteins (Acute-Phase Protein)IBA 01/2008 - 04/2006
2	Serum Amyloid P-ComponentIBA 06/2005 - 02/2004
1	Transaminases (Aminotransferases)IBA 04/2022
1	PPAR deltaIBA 01/2022
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 06/2021
1	Budesonide (Pulmicort)FDA LinkGeneric 01/2021
1	2- (2,6- dimethyl- 4- (3- (4- (methylthio)phenyl)- 3- oxo- 1- propenyl)phenoxyl)- 2- methylpropanoic acidIBA 01/2021
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2020
1	Calcibiotic Root Canal SealerIBA 01/2020
1	Rituximab (Mabthera)FDA Link 12/2019
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 11/2019

Therapy/Procedure

37	Therapeutics 01/2021 - 01/2009
17	Liver Transplantation 12/2021 - 01/2009
3	Transplantation 12/2021 - 03/2012
2	Immunotherapy 01/2020 - 01/2015
2	Colectomy 01/2020 - 10/2016
2	Cholecystectomy 01/2020 - 01/2020
1	Bridge Therapy 01/2021
1	Drug Tapering 09/2020
1	Operative Surgical Procedures 01/2020
1	Gamma Cameras (Gamma Camera) 10/2019
1	Cell- and Tissue-Based Therapy (Cell Therapy) 10/2019